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They were split into three groups

Also stress , be it physical or mental can deplete B12

Numerous microbial species that may produce neurotransmitters, signaling chemicals, or metabolize their precursors into various substances can be found in the human microbiome (163165), during food fermentation and bacterially altered host molecules including bile acids (BAs) (166), tryptophan metabolites, and SCFAs with CNS effects are also produced by the gut bacteria

Nonsteroidal anti-inflammatory drugs (NSAIDs)
