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IsoNet, an isotopologue similarity networking strategy based on mass spectrometry-resolved stable-isotope tracing metabolomics, enables ab initio elucidation of unknown metabolites and their reactions, which is applied to the glutathione metabolic reaction network.

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Higher proportions of oxidized AGT in plasma from pre-eclamptic women compared to matched normotensive pregnant controls (P=0.006), whilst maintaining a similar total plasma AGT concentration were found