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Free Radical Biol Med (2008) 45:54961

R.SunQ.LiuC.MaZ.LiuK.et al (2020)

suggests that tau proteins can activate the NLRP3 inflammasome, which then promotes excessive tau phosphorylation and aggregation by affecting specific tau kinases and phosphatases

Several factors can make this cycle worse, including a deviated septum, enlarged turbinates, nasal polyps, allergies, and underlying inflammatory conditions such as asthma