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Six patients in the treatment group were taking one NRTI, 13 were taking two NRTIs, 3 were taking 3 NRTIs in combination with 1-2 protease inhibitors (PI) and / or non-nucleoside reverse transcriptase inhibitors (NNRTI)

W., Levine, J., & McClure, R

Panel B: Methionine is the precursor of the universal methyl donor, S-adenosylmethionine (SAM)

Pediatr Res 1984;18:815-9

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As a result, the ETC functioning is disrupted, and ATP content becomes significantly depleted, which breaks down metabolic and ionic homeostasis and activates the degradative enzymes such as nucleases, proteases, and phospholipases [182, 188]
