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they also occur idiopathically

Notably, a small cell lung carcinoma cell line, which expresses POMC and ACTH, possesses a hypomethylated POMC promoter, suggesting that ectopic ACTH secretion by tumors may be due to hypomethylation at a relatively early stage in carcinogenesis (41)

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Increased intracellular ROS oxidize cysteine residues on KEAP1, leading to NRF2 release and nuclear translocation [130]

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T-bet is required for the rapid clearance of attenuated rabies virus from central nervous system tissue
