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Moreover, milk phospholipids demonstrated ROS scavenging effects by regulated heme oxygenase-1 (HO-1), an ROS regulator, through activation of nuclear factor erythroid-2-related factor 2 (Nrf2)

Humans have less GST activity or 8,9-epoxide conjugation than rats or mice suggesting that humans are less capable of detoxifying this important metabolite [48]

(2004) state that in the case of chronic neuroinflammation, the cumulative ill effects of microglial and astrocytic activation can contribute to and expand the initial neurodestruction, thus maintaining and worsening the disease process through their actions

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