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P., Piszczek, G

Diet sets the stage

I believe this is very conservative given the Phase 2b PYR-210 clinical trial showed a 57% treatment effect and the hurdle for success in the current Phase 3 PIONEER trial is only 28%

J Cheminform

Tfr1 deficiency in mice protects them from metabolic dysfunction induced by high-fat diets by impairing intestinal lipid absorption, although the underlying mechanism of the adipocyte-intestine link is not fully understood (149)

In general, it is assumed that the two main limiting factors are the levels of cysteine and of the enzyme gamma-glutamyl-cysteine synthetase (also known as glutamate-cysteine ligase)