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Similar to the circulating memory T cells described earlier, noncirculating tissue-resident memory T cells also rely on fatty acid metabolism for long-term maintenance

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After detailed analysis of their structure-activity relationship (SAR), a cyclopropyl analog 75 afforded from the structure of 74 not only displayed a low nanomole inhibitory effect (IC 50 = 8.5 nM), but also possessed reasonable aqueous solubility (0.12 mg/mL in buffer), excellent permeability, and orally bioavailability [182]

10.1111/jnc.12075 3 BallabhP.BraunA.NedergaardM

Quality control includes third-party batch testing using multiple analytical methods
