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Similarly, in -syn preformed fibril (PFF) models, reduced or aberrantly localized AQP4 accelerated -syn aggregation, dopaminergic neuron loss, and behavioral deficits, in part through impaired glymphatic clearance of macromolecules (Braun et al., 2024

However, many other phytochemicals more directly target inflammation: celastrol, for example, powerfully inhibits NFB, a master regulator of inflammation, thereby reducing downstream cytokines and slowing neurodegenerative inflammation [51]

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[DOI] [PubMed] [Google Scholar] Zawada J

10.4049/jimmunol.2000212 J Immunol