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For truly treatment-naive patients, the early results can be striking

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In addition to these metabolic issues, irregular epigenetic modifications [330], impaired activity of nuclear factors such as the upregulation of NFB (nuclear factor B) [331,332] and the downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) activities [333,334], and mitochondrial dysfunction [335] have also been implicated in the overproduction of ROS in DR

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Most patients who are overcoming unhealthy eating habits historically have not been consuming adequate amounts of foods that contain important B vitamins that help fuel energy levels and work to keep the metabolic system functioning properly