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However, it has low water solubility, low gastric absorption, and a severe first-pass effect, resulting in poor bioavailability and unpredictable efficacy

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Copper promotion of angiogenesis in isolated rat aortic ring: role of vascular endothelial growth factor

It is to note that both the cellular lipid hydroperoxides mediated by LOXs enzyme and autoxidized peroxyl radical-mediated LPO may contribute to initiate ferroptosis [38, 40]

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Mi et al., 2023