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Activating cannabinoid receptor 2 preserves axonal health through GSK-3beta/NRF2 axis in adrenoleukodystrophy

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Genazzani AD, Despini G, Czyzyk A, Podfigurna A, Simoncini T, Meczekalski B

002/SBMCH/IHEC/2023/1927, dated 17 March 2023

In a letrozole-induced PCOS mouse model, 160 mg/kg/day NAC for 12 days significantly ameliorated estrous cycle irregularities and ovarian morphology, reduced serum concentrations of LH, the LH/FSH ratio, and T, improved glucose clearance and insulin sensitivity, decreased ROS levels in oocytes and enhanced mitochondrial membrane potential (185)

Mynard V, Guignat L, Devin-Leclerc J, Bertagna X, Catelli MG

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