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Although there is a dearth of data concerning the time course of the subjective effects of heroin, it is in fact commonly acknowledged by users (personal observations in people with heroin use disorder) and experts in the field [13,14,15] that intravenous (i.v.) heroin produces an almost instantaneous surge of ecstatic pleasure (often referred to as flash or rush), lasting about one minute, followed by a pleasant state of stunned calm and detachment, and finally by a sense of well-being and contentment that persists for several hours

"Vitamin B12 Metabolism: A Network of Multi-Protein Mediated Processes"

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Taking 500 mg in the morning and 500 mg in the evening provides steady antioxidant protection throughout the day