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doi: 10.1158/2326-6066.CIR-13-0150 52 NemethZLiMCsizmadiaEDmeBJohanssonMPerssonJLet al

They found that BMSCs and TSG-6 reduced MMP-3 and MMP-13 expression in IL-1-treated NPCs, thus restoring the expression of type II collagen and proteoglycan

In addition, doxorubicin was applied in multiple dosages (3 mg/kg s.c., once weekly through 13 weeks) and in single dosages (7 mg/kg, i.v.) and provoked cardiomyopathy

This approach significantly enhances the stability of sensitive compounds while improving overall delivery efficiency

The phase II study on ivaltinostat for advanced pancreatic ductal adenocarcinoma reports enhanced sensitivity of tumor cells to gemcitabine and erlotinib, presenting it as a potential treatment option