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Herein, we review key features of curcumin involved in biology, pharmacology, and medicinal chemistry and discuss its potential relevance to pathophysiological progress of multiple sclerosis[257] Curcumin, a component of turmeric, has been shown to be non-toxic, to have antioxidant activity, and to inhibit such mediators of inflammation as NFkB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS)[258] In a larger, randomized, double-blind, multicenter trial involving patients with quiescent ulcerative colitis, administration of 1 g of curcumin twice daily resulted in both clinical improvement and a statistically significant decrease in the rate of relapse[259] Our results indicate that curcumin has the potential to protect against cardiac inflammation and may provide a novel therapeutic strategy for autoimmune myocarditis [260] In various chronic illnesses in which inflammation is known to play a major role, curcumin has been shown to exhibit therapeutic potential

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Am J Physiol Cell Mol Physiol 289:L739L749

Shuttles copper into cells through receptor-mediated and passive pathways, stabilizing copper in a redox-controlled form

R., Richdale, A., & Trollor, J

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