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Therefore, the success of cereblon-based PROTACs is due to a set of key factors: Firstly, the most commonly used cereblon ligands are IMiDs, as they exhibit highly specific, strong and biophysically validated E3 ligase binding affinity 43

doi: 10.1002/mds.29429

[DOI] [PubMed] [Google Scholar] 170.Graham S, Courtois P, Malaisse WJ, Rozing J, Scott FW, Mowat AMI

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Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin