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A 2025 systematic review and meta-analysis of the efficacy of various medications used to prevent or reduce ototoxicity in adults receiving cisplatin included eight studies with collectively 431 patients (six randomized controlled trials and two prospective cohort studies) of a wide range of potential otoprotective therapies: diethyldithiocarbamate (intravenously), dexamethasone (intratympanic), N-acetylcysteine (intratympanic), sodium thiosulfate (intravenously), calcium gluconate (intravenously), and aspirin (orally) (18)

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Hence this Genus was not included as a stable dominant microbial member of the Wiltshire brine signature
