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The cause is a restriction of the activity of cytochrome P450 CYP3A4 in the CYP enzyme system in the liver induced by pro-inflammatory cytokines (e.g., IL-6, TNF-, and IL-1Ra), an effect that is stronger at high concentrations of these cytokines (i.e., during highly perturbated and excessive inflammatory events) [18,19,20,21]
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PLoS ONE 8 , e73512 (2013)
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10.1093/femsle/fnad016 54 YuJ.HuQ.LiuJ.LuoJ.LiuL.PengX
