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Interestingly, polycatechol promotes liquid-liquid phase separation of tau and regulates its intermolecular interactions to inhibit the formation of toxic tau aggregates, providing a conceptually innovative approach for treating AD

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Invest New Drugs (2020) 38:181525

Jeho strukturln zvltnost je sulfhydrylov (-SH) skupina, kter mu umouje jedinen fungovn v bukovm prosted

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The molecule retains the complete 70-amino-acid native IGF-1 sequence with two structural modifications a 13-amino-acid N-terminal extension (the Long designation) and an arginine-for-glutamic-acid substitution at position 3 (the R3 designation) which together reduce binding affinity to circulating IGF binding proteins (IGFBPs) by approximately 600-fold while preserving full agonist activity at the IGF-1 receptor