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Besides, the findings presented here illuminate a role for LROs in mounting systemic stress, detoxification, and antimicrobial defenses, which requires a co-operation between ancient and highly conserved processes such as compartmentalization in the endolysosomal system, an ABC membrane transporter and transcriptional stress and innate immune pathways

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For those who were already taking a statin, an equivalent intensity was maintained when the LDL-C level at randomization was below 70 mg/dL, and the intensity was up-titrated when the LDL-C level was 70 mg/dL or greater

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