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The compound demonstrates multimodal regulatory effects, including modulation of key signaling pathways (nuclear factor kappa-B, NLRP3 inflammasome, and nuclear factor erythroid 2-related factor 2) and upregulation of anti-inflammatory cytokines (transforming growth factor- and interleukin-10), collectively contributing to the neuroinflammatory suppression effect of curcumin

[DOI] [PMC free article] [PubMed] [Google Scholar] 220.Kaput J., Monteiro J.P

Aquatic Toxicol 101:1330 Belrose JC, Xie YF, Gierszewski LJ, MacDonald JF, Jackson MF (2012) Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

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