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The inability to adapt to the different cellular and environmental needs/stressors results in metabolic inflexibility, which ultimately leads to disease states like insulin resistance, lipid accumulation, and an inability to maintain homeostatic balance [24,25,26] (Figure 6)

The absence of pharmacokinetic or pharmacodynamic interaction studies means healthcare providers must rely on theoretical considerations and the known pharmacology of each component when patients inquire about combination use

Published 2021 Mar 2

In the clinic, we find that for immediate relief, magnesium citrate, magnesium oxide, or milk of magnesia can work within hours, while senna or aloe vera offer overnight results

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