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Numerous processes enable cancer cells to withstand the cytostatic and cytotoxic effects of medications, which leads to drug resistance in these cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Sun Q., Zhong W

They improve the therapeutic indices of the pharmacological molecules enclosed in them dramatically

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While fusion is generally thought to be protective in times of stress by allowing content mixing and sharing of healthy mitochondria to counteract damage to others, it has also been shown to increase the spread of detrimental mtDNA in a model of sepsis, suggesting it may exacerbate certain inflammatory conditions

Using human embryonic stem cells (hESCs), a research group showed the dose dependency of OTA toxicity ( Mycotoxins mount variable challenges to humans at different stages of life (Figure 7)