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In addition, BHB inhibits NLRP3 activation, resulting in a reduced release of inflammatory factors, particularly IL-1 and IL-18, by inhibiting caspase-1 activation (176, 190)

[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Corona G., Sansone A., Pallotti F., Ferlin A., Pivonello R., Isidori A.M., Maggi M., Jannini E.A

In patients who were clinically diagnosed with depression, significant differences in lymphocytes were found between male and female patients (Gialluisi et al., 2020)
However, their specific regulatory network and the dynamic relationship under pathological conditions remain unclear, warranting further studies to uncover their molecular mechanisms and biological significance

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