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Description
The first of these clinically relevant multidrug efflux pumps to be described (in 1976) was P-glycoprotein: human P-glycoprotein is encoded by the ABCB1 gene (formerly known as the MDR1 gene) (Gottesman et al, 2002
This substrate-dependent regulation is further corroborated by recent studies, Yang et al
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Treatment with nitrite prevents reactive oxygen species generation in the corpora cavernosa and restores intracavernosal pressure in hypertensive rats
Souza JM, Peluffo G, Radi R (2008) Protein tyrosine nitrationfunctional alteration or just a biomarker
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