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References Global Initiative for Chronic Obstructive Lung Disease (GOLD)

In addition to BRCA genes, mutations in other high-penetrance genes such as TP53 (associated with Li-Fraumeni syndrome) and PTEN (linked to Cowden syndrome) have been found to be associated with familial breast cancer, as these genes are heritable, keeping women at potential risk to develop cancer during their lifetime ( PALB2, ATM , and CHEK2 (63)

doi: 10.1038/srep21934 90 ShomaliA.AliniaeifardS.DidaranF.LotfiM.MohammadianM.SeifM.et al

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Anytime the skin is penetrated, it creates an opening for infection