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doi: 10.3389/fendo.2020.00160 96 Van DalumJMelumVJWoodSHHazleriggDG

Noteworthy, all these factors act by promoting an increase in oxidative stress via mitochondrial defects and the production of ROS and RNS [132]

Interestingly, PHGDH also affects tumor biology independently of its effects in serine metabolism, for example, directly interacting with the RNA-binding protein Poly(rC)-binding protein 2 (PCBP2), and inhibiting its proteasomal degradation

In situ immunofluorescence of NRF2 also indicated this protein is highly expressed and present in the nucleus of A549 cells, with lesser expression in the nucleus of H23 cells (representative results shown in Supplementary Fig

doi: 10.1021/acs.chemrev.0c01213 [DOI] [PubMed] [Google Scholar] 23.Kapoor G, Saigal S, Elongavan A

LARERA aggiorna ogni 3 mesi le componenti: Quota fissa (oneri generali)
