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Elsevier, Amsterdam, The Netherlands, pp 639667 Baker AF, Adab KN, Raghunand N, Chow H, Stratton SP, Squire SW, Boice M, Pestano LA, Kirkpatrick DL, Dragovich T (2013) A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers

Some of the grading scales usually used in clinical practice to evaluate peripheral neuropathy associated with chemotherapy include Total Neuropathy Score clinical version (TNSc), National Cancer Institute-Common Toxicity Criteria (NCI-CTC), modified Inflammatory Neuropathy Cause and Treatment (INCAT) group sensory sum score (mISS), European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and CIPN (chemotherapy-induced peripheral neuropathy) 20 quality-of-life measures [23,24,25,26,27] (Table 3)

The two groups matched by sex and, therefore, there was no significant difference in this variable

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A systematic review of randomized controlled trials found that NAC improved ovulation and pregnancy rates compared to placebo in women with PCOS, though the authors noted variability in study quality.66 More recent meta-analytic research continues to evaluate NAC across both reproductive and metabolic outcomes, suggesting it may offer measurable benefits for some individuals particularly when ovulatory dysfunction and metabolic stress are present.67 You can explore how NAC is used in PCOS research and see our top-rated options in our complete guide to NAC supplements