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A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies

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It may promote abnormal angiogenesis (new blood-vessel growth), raising theoretical concerns in patients with cancer history

Epigenetic mechanisms regulate the expression of genes crucial for immune response, neuronal function, and synaptic plasticity in neuroinflammatory processes

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