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Lipoxygenase/Leukotriene Pathway Activation of 5-lipoxygenase (LOX) in ( primarily expressed in leukocytes ) results in the conversion of arachidonic acid to leukotrienes that function as inflammatory mediators (Wikipedia) resulting in: bronchoconstriction increased secretion of mucus leukocyte chemotaxis histamine release This pathway has its greatest clinical relevance in the pathophysiology of asthma
Therefore, further exploration of the mechanism of action of Kla and identification of Kla-related catalytic enzymes may provide more targets for tumor treatment
[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Katz B
Abstract Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence play an important role in the regulation of the cell's fate
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The NAD + is perpendicular to the -strands of the Rossmann fold
