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AMD primarily affects people 50 and older, and due to the rapidly aging nature of the global population, the prevalence of AMD is expected to increase by over 46% and affect approximately 288 million people worldwide by 2040

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317 The mechanism of SGLT-is and GLP-1 on CVD benefits might be that they improve mitochondrial energy metabolism and reduces oxidative stress though activation of AMPK signaling pathways 318