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Common causes include dietary deficiency (eg, vegan or vegetarian diet, low intake of meat or dairy products), use of proton-pump inhibitors or H2 blockers, and poor B12 absorption due to age-related changes in the stomach (eg, atrophic gastritis)

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151 , U25U37 (2004)

25,26 Furthermore, reduced concentrations of the reaction substrate GSH facilitate the generation and accumulation of reactive oxygen species (ROS), both hallmarks of calcification

Structure of Glutathione To understand glutamic acid fully, we must understand its role in glutathione

71 ROS can also activate downstream effectors like PKC 72 and JNK, 73 which are independently associated with DPN pathology