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Following injury, macrophages and other innate immune cells rapidly infiltrate the wound site, secreting pro-inflammatory cytokines such as TNF-, IL-1 and chemokines that orchestrate early inflammatory responses and influence both pain and healing processes [41,42]

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Diagnoses were confirmed by two endocrinologists using specific biomarkers, such as the levels of pancreatic autoantibodies, in accordance with the Chinese Type 1 Diabetes Guidelines and the American Diabetes Associations criteria