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Well- known examples of such therapy include the use of methotrexate in cancer chemotherapy to semi-selectively inhibit DNA synthesis of malignant cells, the use of aspirin to inhibit the synthesis of prostaglandins which are at least partly responsible for the aches and pains of arthritis, and the use of sulfa drugs to inhibit the folic acid synthesis that is essential for the metabolism and growth of disease-causing bacteria

Fajgelj A (1999) Harmonized guidelines for the use of recovery information in analytical measurement

The cornification process proceeds by the attachment of various other proteins to the multi-protein complex at the cell membrane

& Hagspiel, K

In contrast, Webster et al

High dose ( 0.5 mg/kg/d) or long-term use may lead to hypoglycemia, especially in patients with diabetes or insulin resistance