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Nano-shields: exploring the role of antioxidant mimicking nanoparticles as regenerative therapy in spinal cord injury

10.1038/s41467-019-08680-6 152

Although selective permeability represents the most significant challenge, the BBB is also equipped with efflux transporters, such as P-gp and MRPs, that actively eliminate drugs from the brain

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Treatment with an iron chelator eliminated both protein nitration and liver injury in the absence of LPO [80], suggesting again that under normal conditions, APAP-induced cell death is unlikely to involve ferroptosis [80]

LL, LS, ZH, and KC searched the literature and participated in the manuscript discussion