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If you are achieving your research objectives at 1.0mg with manageable side effects, there is no clinical requirement to increase further

Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes

Lancet 354, 20482049

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Some animal and early-phase studies noted elevated inflammatory cytokines (IL-6, TNF-) at higher doses, though clinical relevance in humans at therapeutic doses remains unclear

Finally, the efficacy of ENPDOX in the treatment of GBM-bearing mice was assessed