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Fumarate is an oncometabolite and a potent inhibitor of prolyl 4-hydroxylase (P4H), which is a negative regulator of HIF-1

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Interestingly, the regions of GUVs without GAS7 were later completely covered by GAS7, with the progression at the edges of the GAS7 assembly

The mitochondrial permeability transition pore: channel formation by F-Atp synthase, integration in signal transduction, and role in pathophysiology