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When NRF-2 is exposed to inflammation or oxidative stress (OS), it phosphorylates and translocates into the nucleus, giving rise to the transcription of proteins and antioxidant enzymes [7]

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Of the monitored tryptophan metabolites, only 5-hydroxyindolacetic acid was positively correlated with the severity of depression, total cholesterol, and negatively with brain-derived neurotrophic factor and glutathione peroxidase

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