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Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion

5.2.2 Ameliorating inflammation and oxidative stress Dihydroartemisinin reduces the expression of TGF-1, a key factor in fibrosis, and inhibits the activation of JAK2 and STAT3, thereby decreasing the expression of the inflammatory factors, such as IL-1, IL-6, TNF-, and chemokine ligand 3, and reducing the infiltration of inflammatory cells (You et al., 2022)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Tepperman B.L., Whittle B.J
Additionally, inhibition of SLC1A5-mediated glutamine transport by knockdown of SLC1A5 or adding SLC1A5 inhibitor L--glutamyl-p-nitroanilide (GPNA) attenuates mTOR activation and proliferation of breast cancer cells, and these inhibitory effects are more prominent in TNBC tumor cells compared to luminal subtypes (88)