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Cross-species efficacy of AAV-mediated ARSA replacement for metachromatic leukodystrophy

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After treatment initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

Depending on the severity of your deficiency, you may need to receive multiple B12 shots within the first few weeks of treatment and then regularly every one to three months after that

This explains why, in patients with mutations in the SLC6A8 gene, there is a lack of sufficient brain creatine

10.1111/j.1471-4159.2005.03404.x J