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Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society 54 (S6): S3S12
At its IC50 concentration, vincristine induced significant downregulation of Ribonucleotide Reductase M2 (RRM2), involved in DNA damage repair and cell cycle regulation ( Supplementary Table S1 )
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Research suggests that its activity may be linked to VEGF and TGF- signaling, fibroblast activation, and endothelial function
