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[DOI] [PMC free article] [PubMed] [Google Scholar] 156.Stefano MD et al

Some patients experience headache, others may feel nauseated

Declining NAD[+] induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
B12 also plays a role in maintaining your nerve cells, helping them work properly and keeping your brain sharp

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So the 100% figure is an assumption from how systemic administration generally behaves, not a measured number for this compound
