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Since we did not detect a decrease in pyruvate in the cortex (Supplementary Table 7), these results could suggest there may be reduced lactate dehydrogenase activity in astrocytes, as lactate can be produced downstream from glucose to support energy needs in neurons

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Far from being a single procedural step, a FIH trial is built on a broad body of scientific, regulatory and operational work designed to ensure that the transition from preclinical research to human investigation takes place within a rigorous framework focused on safety, quality and evidence generation

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This study shows that inhibition of ligand binding to the IGF1 receptor inhibits tumour progression