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Normally, Nrf2 is fixed in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap-1)

Targeted upregulation of pyruvate dehydrogenase kinase-4 in slow-twitch skeletal muscle underlies the stable modification of regulatory characteristics induced by high-fat feeding

J Clin Investig 1989

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Kamintsky, L

For the diagnosis of Lyme arthritis, PCR testing of synovial fluid may be considered to guide treatment decisions, but culture is not recommended.7 For this patient, the diagnosis of Lyme disease was based on the presence of erythema migrans and history of an engorged tick attached to the neonates skin