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In prior experiments by Liu and colleagues, high-dose copper exposure induced hepatocyte apoptosis through the mitochondrial apoptosis pathway, leading to mitochondrial membrane depolarization, release of cytochrome c, cleavage of caspase-9 and caspase-3, increased levels of Bak and Bax, decreased Bcl-2, and ultimately inducing apoptosis (31)

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SULFATE TRANSPORTERS Sulfate transporters are the most prominent group of S-metabolite transporters in plants because sulfate is the major source of sulfur taken up from the soil and because it is the most abundant S-containing metabolite in plant cells