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The ANOVA results showed a significant reduction in migraine frequency across various supplemented and control groups ( p = 0.008)

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Altogether, the results of these experiments provide strong evidence that the increased aggregation propensity of ApoE4 compared to the other isoforms is driven by the structural changes induced by the C112R substitution to the self-associating interface

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Biochim Biophys Acta 2011