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GSTs are expressed predominantly in the liver and are involved in metabolizing various compounds

Our reviewer highlights similar trends, particularly in the discussion of PTEN-deficient tumors, where macrophage polarization is influenced by metabolic shifts, further reinforcing the idea that metabolism-targeted therapies could play a role in modulating TAM activity (165)

Seifar et al., -Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review, Nutr

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There are two main types of skin aging: intrinsic (natural or chronological) aging, which occurs inevitably within the body, and extrinsic (photoaging), which is caused by external factors like environmental pollution, UV light, and lifestyle (alcohol, smoking, etc.)

Thanks to these promising preclinical results, a CNTF derivative was tested in clinical trials in which significant weight loss was observed 17,18 , indicating that activation of the CNTFR can regulate food intake and metabolism