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Growth factor-derived HLCs were maintained in medium consisting of Williams E Medium, 10% FBS, 1% GlutaMax, 1% NEAA, 1% Penicillin/Streptomycin (Thermo Fisher Scientific), 1% Insulin-Transferrin-Selenium supplement (Sigma), 10 7 M dexamethasone (Sigma Aldrich)

Another critical period may be affected by oxidative stress or inflammation of the fetal brain, potentially due to inadequate microglial immunity, which can lead to CNS inflammatory changes that disrupt typical neurodevelopment

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When oxidative stress due to low glutathione interferes with cell communication and signaling in an autistic child's brain, the child will naturally suffer deficits in speech, learning, focus and other cognitive issues

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Therefore, the role of STAT3 in c-MET signaling is probably context- and tissue-dependent