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Understanding the relationship between cancer associated cachexia and hypoxia-inducible factor-1

Briefly, dextran sulfate sodium (DSS) (MP biomedicals, #160110) was administered to C57BL6 mice (36 months old) for 5 days

PK drug scientists in early discovery are often asked if efficacy is Cmax or AUC driven following early preclinical pharmacology assessments this question is less about PK and relates more to the test articles affinity and reversibility with the molecular disease target

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Fibrinogen interaction with astrocyte ICAM-1 and prPC results in the generation of ROS and neuronal death