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While both CDDO and its derivatives, namely CDDOtrifluoromethylamide (CDDOTFEA) and CDDOBardoxoloneMethyl (CDDOMe), activate NRF2 in a similar way, only CDDOMe and CDDOTFEA suppress BACH1 through reducing its nuclear level, making them dual KEAP1/BACH1 inhibitors impeding the invasion of lung cancer cells

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It acts by reversibly inhibiting pancreatic lipase enzyme, thus preventing the hydrolyzation and absorption of dietary fat by approximately 30%, and thereby decreasing the caloric intake of obese patients [32]

Kinetics and stoichiometry of fatty acid peroxidation

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MR-PRESSO applies a leave-one-out approach to identify the genetic variant(s) differentially driving the associations [41], i.e., outliers, and provide a corrected estimate after removing the outliers [42]